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年度別業績リスト (2000年~)


2017年

Madhu Chennapuram, U. V. Subba Reddy, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita and Hiroto Nakano

“Hybrid-Type Squaramide-Fused Amino Alcohol Organocatalysts for Enantioselective Nitro-Aldol Reaction of Nitromethane with Isatins”, European Journal of Organic Chemistry, 2017, 1638-46 (2017). →Link


2016年

Toshihisa Takahashi, U.V. Subba Reddy, Yoshihito Kohari, Chigusa Seki, Taniyuki Furuyama,

Nagao Kobayashi, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita,

Hiroto Nakano

“Simple primary β-amino alcohol catalyzed enantioselective Diels-Alder reaction of 3-hydroxy-2-pyridones”,

Tetrahedron Letters, 57 (51), 5771-5776 (2016).  →Link


Ayumi Ogasawara, U.V. Subba Reddy, Chigusa Seki, Yuko Okuyama, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

“2-Azanorbornane-based amine organocatalyst for enantioselective aldol reaction of isatins with ketones”, Tetrahedron: Asymmetry, 27(20–21), 1062-1068 (2016).  →Link


中野博人,熊谷 淳,U. V. Subba Reddy,関 千草,奥山祐子,權 垠相,“アミノアルコールおよびその関連化合物を有機分子触媒として用いた不斉付加環化反応の開発”,有機合成化学協会誌, 74 (7), 720-731 (2016).  →Link


Jo Kimura, Ummareddy Venkata Subba Reddy, Yoshihito Kohari, Chigusa Seki, Yasuteru Mawatari, Koji Uwai, Yuko Okuyama, Eunsang Kwon, Michio Tokiwa, Mitsuhiro Takeshita, Tatsuo Iwasa and Hiroto Nakano

“Simple Primary Amino Amide Organocatalyst for Enantioselective Aldol Reactions of Isatins with Ketones” European Journal of Organic Chemistry, 2016, 3728-3756 (2016). →Link


Ummareddy Venkata Subba Reddy, Madhu Chennapuram, Chigusa Seki, Eunsang Kwon, Yuko Okuyama and Hiroto Nakano

“Catalytic efficiency of primary β-amino alcohols and their derivatives in organocatalysis” European Journal of Organic Chemistry, 2016 (24), 4124–4143 (2016). →Link


2015年

Jun Kumagai, Teppei Otsuki, U. V. Subba Reddy, Yoshihito Kohari, Chigusa Seki, Koji Uwai, Yuko Okuyama,  Eunsang Kwon, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano

“Chiral primary amino alcohol organobase catalysts for the asymmetric Diels-Alder reactions of anthrones with maleimides” Tetrahedron: Asymmetry, 26 (24), 1423-1439 (2015). →Link


Teppei Otsuki, Jun Kumagai, Yoshihito Kohari, Yuko Okuyama, Eunsang Kwon, Chigusa Seki, Koji Uwai, Yasuteru Mawatari, Nagao Kobayashi, Tatsuo Iwasa, Michio Tokiwa, Mitsuhiro Takeshita, Atushi Maeda, Akihiko Hashimoto, Kana Turuga, Hiroto Nakano

“Silyloxy Amino Alcohol Organocatalyst for Enantioselective 1,3-Dipolar Cycloaddition of Nitrones to

α,β- Unsaturated Aldehydes” European Journal of Organic Chemistry, 2015 (33), 7292-7300 (2015). →Link


Kaoru Sano, Yoshihito Kohari, Hiroto Nakano, Chigusa Seki, Mitsuhiro Takeshita, Michio Tokiwa, Yoshihiko Hirose, Koji Uwai

“Lipase-Catalyzed Domino Michael-Aldol Reaction of 2-Methyl-1,3-Cycloalkanedione and Methyl Vinyl Ketone for the Synthesis of Bicyclic Compounds” Synthetic Communications, 46 (1), 46-54 (2015).  →Link


Jun Kumagai, Yoshihito Kohari, Chigusa Seki, Koji Uwai, Yuko Okuyama, Eunsang Kwon, and Hiroto Nakano

“Chiral Primary Amino Amide Alcohol Organocatalyst for the Asymmetric Michael Addition of 4-Hydroxycoumarin with α,β-Unsaturated Ketones” Heterocycles, 90 (2), 1124-1134 (2015). →Link


2014年

Yoshihito Kohari, Yuko Okuyama, Eunsang Kwon, Taniyuki Furuyama, Nagao Kobayashi, Teppei Otuki, Jun Kumagai, Chigusa Seki, Koji Uwai, Gang Dai, Tatsuo Iwasa and Hiroto Nakano

“Enantioselective Diels–Alder Reaction of 1,2-Dihydropyridines with Aldehydes Using β-Amino Alcohol Organocatalyst” J. Org. Chem. 79 (20), 9500-9511 (2014). →Link


Hiroto Nakano, Yuko Okuyama, Eunsang Kwon, “Chiral Oxazolidine Catalyst for Asymmetric Synthesis”

Heterocycles, 89 (1), 1-26 (2014). →Link


2013年

Kaoru Sano, Shun-ichi Saito, Yoshihiko Hirose, Yoshihito Kohari, Hiroto Nakano, Chigusa Seki, Michio Tokiwa, Mitsuhiro Takeshita, Koji Uwai “Development of a Novel Method for Warfarin Synthesis via Lipase-catalyzed Stereoselective Michael Reaction” Heterocycles, 87 (6), 1269-1278 (2013). →Link


2012年

山崎隆喜,馬渡康輝, 波川啓土,中野博人,田畑昌祥, “疎水性芳香族ポリエステル中の水分子の役割”

高分子論文集, 69 (9), 511-527 (2012). →Link


Yuki Sakuta, Yoshihito Kohari, N. D. M. Romauli Hutabarat, Koji Uwai, Eunsang Kwon, Yuko Okuyama, Chigusa Seki, Haruo Matsuyama, Nobuhiro Takano, Michio Tokiwa, Mitsuhiro Takeshita, and Hiroto Nakano, ”Chiral Primary Amino Silyl Ether Organocatalyst for the Enantioselective Diels-Alder Reaction of 1,2-Dihydropyridine with Aldehydes” Heterocycles, 86 (2), 1379-1389 (2012). →Link


N. D. M. Romauli Hutabarat, Chigusa Seki, Takashi Shimizu, Masafumi Hirama, Yoshihito Kohari, Hiroto Nakano, Koji Uwai, Nobuhiro Takano, Eunsang Kwon and Haruo Matsuyama, “ Highly Enantioselective Synthesis of Isoquinuclidine by Diels-Alder Reaction of 1,2-Dihydropyridine Utilizing Chiral Bisoxazoline-Cu(II) Complex” Heterocycles, 86 (1), 203-217 (2012). →Link


Chigusa Seki, Masafumi Hirama,Takuya Sato, Saya Takeda, Yoshihito Kohari, Kazuhiro Ishigaki, Masafumi Ohuchi, Kiyoshi Yokoi, Hiroto Nakano, Koji Uwai, Nobuhiro Takano, Kazuyuki Umemura and Haruo Matsuyama,“ One Step Synthesis of Optically Active Diazabicyclo[3.3.0]octanes or Diazabicyclo[4.3.0]nonanones by Asymmetric Conjugate Addition of Cyclic Hydrazines” Heterocycles, 85 (5), 1045-1052 (2012). →Link


中野博人, 奥山祐子, 竹下光弘, 權 垠相, 小針良仁, 松山春男, “キラルオキサゾリジン類を用いた触媒的不斉合成反応の開発” 有機合成化学協会誌, 70 (2),142-153 (2012). →Link


中野博人, 權 垠相, 奥山祐子, “ アミノ酸関連有機化合物の触媒作用を利用した高光学純度タミフル合成中間体の新しい合成法” ファインケミカル, 41, 45-54 (2012).


Chigusa Seki, Masafumi Hirama, N.D.M. Romauli Hutabarat, Junko Takada, Chonticha Suttibut, Hideto Takahashi, Takuya takaguchi, Yoshihito Kohari, Hiroto Nakano, Koji Uwai, Nobuhiro Takano, Mitsukuni Yasui, Yuko Okuyama, Mitsuhiro Takeshita, Haruo Matsuyama, “Asymmetric synthesis of isoquinuclidines by Diels-Alder reaction of 1,2-dihydropyridine utilizing a chiral Lewis acid catalyst” Tetrahedoron, 68 (6), 1774-1781 (2012). →Link


Yuko Okuyama, Kenichi Osone, Hiroto Nakano, Mitsuhiro Takeshita, “New Hydrazine-Based Organocatalyst for Asymmetric Diels-Alder Reaction of 1,2-Dihydropyridines” Heterocycles, 84 (2), 1209-1216 (2012). →Link


Masafumi Hirama, Chonticha Suttibut, N.D.M.R Hutabarat, Chigusa Seki, Noritaka Sakuta, Takefumi Tsuchiya, Yoshihito Kohari, Hiroto, Hiroto Nakano, Koji Uwai, Nobuhiro Takano, Mitsukuni Tasui, Yuko Okuyama, Kenichi Osone, Mitsuhiro Takeshita, Haruo Matsuyama, “Asymmetric synthesis of isoquinuclidine by Diels-Alder reaction of 1,2-dihydropyridine and chiral dienophile utilizing a chiral Lewis acid” Heterocycles, 84 (1), 377-384 (2012). →Link


中野博人, “オキサゾリジン化合物の触媒作用を利用した高光学純度タミフル合成中間体の新しい合成方法” 月刊 化学工業,  63(1), 31-37 (2012).


2011年

Chonticha Suttibut, Yoshihito Kohari, Ko Igarashi, Hiroto Nakano, Masafumi Hirama, Chigusa Seki, Haruo Matsuyama, Koji Uwai, Nobuhiro Takano, Yuko Okuyama, Kenichi Osone, Mitsuhiro Takeshita, Eunsang Kwon, “A highly enantioselective Diels Alder reaction of 1,2-dihydropyridine using a simple beta-amino alcohol organocatalyst for a practical synthetic methodology of oseltamivir intermediate” Tetrahedron Lett., 52, 4745-4748, (2011). →Link


2010年

Hiroto Nakano, Kenichi Osone, Mitsuhiro Takeshita, Eunsang Kwon, Chigusa Seki, Haruo Matsuyama, Nobuhiro Takano, Yoshihito Kohari, A novel chiral oxazolidine organocatalyst for the synthesis of an oseltamivir intermadiate using a highly enantioselective Diels-Alder reaction of 1,2-dihydropyridine” Chem. Commun. 46, 4827-4829, (2010). →Link


Yoshihito Kohari, Yukio Hoshino, Haruo Matsuyama, Hiroto Hakano, “Efficient synthetic methodology of biflavones having a ring-a ring of two flavone units using Suzuki cross-coupling reactions” Heterocycles, 81, 1871-1879, (2010). →Link


Yoshihito Kohari, Yukio Hoshino, Haruo Matsuyama, Hiroto Hakano, “Efficient synthetic methodology of flav-3-enes using reductive elimination of flav-4-triflate” Heterocycles, 82, 843-850, (2010). →Link


Masafumi Hirama, Yuji Kato, Chigusa Seki, Hiroto Nakano, Mitsuhiro Takeshita, Noriko Oshikiri, Masahiro Iyoda, Haruo Matsuyama, “An Efficient Synthesis of Chiral Isoquinuclidines by Diels-Alder Reaction Using Lewis Acid Catalyst”, Tetrahedron, 66, 7618-7624, (2010). →Link


2009年

Yuko Okuyama, Hiroto Nakano, Yuki Watanabe, Mika Makabe, Mitsuhiro Takeshita, Koji Uwai, Chizuko Kabuto, Eunsang Kwon, “Organocatalytic activity of 4-hydroxy-prolinamide alcohol with different noncovalent coordination sites in asymmetric Michael and direct aldol reactions” Tetrahedron Lett. 50, 193-197, (2009). →Link


Yasuhiro Nishiuchi, Hiroto Nakano, Yuta Araki, Rina Sato, Reiko Fujita, Koji Uwai, Mitsuhiro Takeshita, “Reactivity and Efficient Recycling of a Chiral Pd-BINAP Catalyst for Catalytic Asymmetric Diels-Alder Reaction in Ionic Liquid” Heterocycles, 77, 1323-1331 (2009). →Link


2008年

Hiroto Nakano, Yasuhiro Nishiuchi, Kouichi Takahashi, Reiko Fujita,Koji Uwai, Mitsuhiro Takeshita, “Chiral Cationic Pd-phosphinooxazolidine Catalysts for a Highly Efficient Asymmetric Diels-Alder Reaction in Ionic Liquids”, Heterocycles, 76, 381-390 (2008). →Link


2007年

Kouichi Takahashi, Hiroto Nakano, Reiko Fujita, “Reuse of Chiral Cationic Pd- Phosphinooxazolidine Catalysts in Ionic Liquids: A Highly Efficient Catalytic Asymmetric Diels-Alder Reactions” Chem. Commun. 263-265 (2007). →Link


Masato Hoshino, Tsuyoshi Taguchi, Hiroto Nakano, Hiroshi Tomisawa, Hisao Matsuzaki, Reiko Fujita, “Reaction of 2-Alkylthiopyridinium Salts with Active Methylene Compounds” Hetrocycles, 74, 791-802 (2007). →Link


中野博人,奥山祐子,高橋康一,藤田礼子,甲千寿子,“アセタール構造を有する不斉配位子の創製とそのパラジウム触媒不斉反応への応用”,有機合成化学協会誌,65 (12), 1191-1202 (2007). →Link


2006年

Hiroto Nakano, Natsumi Tsugawa, Kouichi Takahashi, Yuko Okuyama, Reiko Fujita, “An Efficient Synthetic Methodology of Chiral Isoquinuclidines by the Enantioselective Diels-Alder Reaction of 1,2- Dihydropyridines Using Chiral Cationic Palladium- Phosphinooxazolidine Catalyst” Tetrahedron, 62, 10879-10887 (2006). →Link


2005年

Gustavo Rios-Morenoa, Ruben A. Toscanoa, Rocio Redonb, Hiroto Nakano, Yuko Okuyama, and David Morales-Moralesa, “Rhodium (I) Complexes with Phosphinooxathiane (POT) and Phosphinooxazolidine (POZ) Ligands: The Crystals Structures of [(POTRh(CO)Cl) and [(POZ)Rh(CO)Cl]” Inorganica Chimica Acta, 358, 303-309 (2005). →Link


Hiroto Nakano, Kouichi Takahashi, Yuri Suzuki, and Reiko Fujita, “Polymer- Supported Chiral Phosphinooxathiane Ligands for Palladium- Catalyzed Asymmetric Allylations” Tetrahedron: Asymmetry, 16, 609-614 (2005). →Link


Hiroto Nakano, Kouichi Takahashi, and Reiko Fujita, “Polymer-Supported Chiral Phosphinooxazolidine Ligands for Palladium-Catalyzed Asymmetric Allylic Alkylations and Diels-Alder Reactions” Tetrahedron: Asymmetry, 16, 2133-2140 (2005). →Link


Yuko Okuyama, Hiroto Nakano, Yuka Saito, Kouichi Takahashi, and Hiroshi Hongo, “Chiral Sulfideoxathiane Ligands for Palladium-Catalyzed Asymmetric Allylic Alkylation” Tetrahedron: Asymmetry, 16, 2551-2557 (2005). →Link


Hiroto Nakano, Natsumi Tsugawa, and Reiko Fujita, “The Highly Enantioselective Diels-Alder Reaction of 1,2-Dihydro-pyridine using Chiral Cationic Palladium-Phosphino oxazolidine Catalyst for The Synthesis of Chiral Isoquinuclidines” Tetrahedron Lett. 46, 5677-5681 (2005). →Link


Kouichi Takahashi, Hiroto Nakano, and Reiko Fujita, “A Concise and Practical Catalytic Asymmetric Synthesis of (-)-CP-99,994 and (-)-L-733,061” Tetrahedron Lett. 46, 8927-8930 (2005). →Link


2004年

Hiroto Nakano, Kouichi Takahashi, Yuko Okuyama, Chieko Senoo, Natsumi Tsugawa, Yuichiro Suzuki, Reiko Fujita, Kazuo Sasaki, and Chizuko Kabuto, “Chiral Phosphinooxazolidine Ligands for Palladium- and Platinum-Catalyzed Asymmetric Diels-Alder Reactions” J. Org. Chem. 69, 7092-7100 (2004). →Link


Hiroto Nakano, Kouichi Takahashi, and Reiko Fujita, Polymer-supported “Phosphinooxathiane as Ligands for Palladium-catalyzed Asymmetric Allylations”, Heterocycles, 64, 407-416 (2004). →Link


2003年

Yuko Okuyama, Hiroto Nakano, Mayumi Igarashi, Chizuko Kabuto, and Hiroshi Hongo, “A New Chiral Pyrrolidine- and Pyrrolidinoneethanols for Enantioselective Addition of Diethylzinc to Arylaldehydes” Heterocycles, 59, 635-643 (2003). →Link


Reiko Fujita, Kanako Oikawa, Toshiteru Yoshisuji, Yuko Okuyama, Hiroto Nakano, and Hisao Matsuzaki, “Cycloaddition of 1-Substituted 1,3-Butadienes with 4- or 3-Substituted 2(1H)-Quinolones Acting as Dienophiles” Chem. Pharm. Bull. 51, 295-300 (2003). →Link


Yuko Okuyama, Hiroto Nakano, Kouichi Takahashi, Hiroshi Hongo, and Chizuko Kabuto, “Novel and efficient chiral sulfideoxathiane ligands for palladium- catalyzed asymmetric allylic alkylation” Chem. Commun. 524-525, (2003). →Link


Hiroto Nakano, Jun-ichi Yokoyama, Yuko Okuyama, Reiko Fujita, and Hiroshi Hongo, “Novel chiral xylofuranose-based phosphinooxathiane and phosphinooxazinane ligands for palladium-catalyzed asymmetric allylations”, Tetrahedron: Asymmetry, 14, 2361-2368 (2003). →Link


Hiroto Nakano, Yuko Okuyama, Ryo-suke Takahashi, and Reiko Fujita, “New chiral phosphinooxathiolane ligands for palladium-catalyzed asymmetric allylations” Heterocycles, 61, 471-479 (2003). →Link


2002年

Hiroto Nakano, Yuko Okuyama, Kazuyuki Fushimi, Ryo, Yamakawa, Daisuke Kayaoka, and Hiroshi Hongo, “New Chiral Pyrrolidinyl- and 2-Azanorbornyloxazolidine Ligands for Enantioselective Addition of Diethylzinc to Aldehydes” Heterocycles, 56, 457-466 (2002). →Link


Laura F. Basil, Hiroto Nakano, Rogelio Frutos, Michael Kopach, and A. I. Meyers, “Asymmetric tandem additions to chiral 2,3-dihydronaphthyl- oxazolines: synthesis of the triptoquinone/triptinin a ring system” Synthesis, 14, 2064-2074 (2002). →Link


Hiroto Nakano, Jun-ichi Yokoyama, Reiko Fujita, and Hiroshi Hongo, “Novel chiral xylofuranose-based phosphinooxathiane and phosphinooxazinane ligands for palladium-catalyzed asymmetric tandem allylic allylation” Tetrahedron Lett. 43, 7761-7764 (2002). →Link


Hiroto Nakano, Yuichiro Suzuki, Chizuko Kabuto, Reiko Fujita, and Hiroshi Hongo, “Chiral phosphinooxathiane ligands for catalytic asymmetric Diels-Alder Reaction” J. Org. Chem. 67, 5011-5014 (2002). →Link


Hiroto Nakano, Yuko Okuyama, Yuichiro Suzuki, Reiko Fujita, and Chizuko Kabuto, “A novel and efficient chiral palladium-phosphinooxazolidine catalyst for the enantioselective Diels-Alder reaction” Chem. Commun. 1146-1147 (2002).  →Link


Yuko Okuyama, Hiroto Nakano, Chizuko Kabuto, Erica Nozawa, Kouichi Takahashi, and Hiroshi Hongo, “New chiral ligands, pyridinooxathianes, for palladium-catalyzed asymmetric allylic alkylation” Heterocycles, 58, 457-469 (2002). →Link


2001年

Hiroto Nakano, Yuko Okuyama, Mariko Yanagida, and Hiroshi Hongo, “Palladium-Catalyzed Asymmetric Allylic Substitution Reactions Using New Chiral Phosphinooxathiane Ligands” J. Org. Chem. 66, 620-625 (2001). →Link


Hiroto Nakano, Yuko Okuyama, Kazuto Iwasa, and Hiroshi Hongo, “Synthesis of New Chiral Catalysts, 2-Azanorbornyloxazolidines for Enantioselective Addition of Diethylzinc to Aldehydes” Heterocycles, 54, 411-418 (2001). →Link


2000年

Yuko Okuyama, Hiroto Nakano, and Hiroshi Hongo, “New Chiral Ligands, Pyrrolidinyl- and 2-Azanorbornyl-phosphino- oxazolidines for Palladium- Catalyzed Asymmetric Allylation” Tetrahedron: Asymmetry, 11, 1193-1198 (2000). →Link


Hiroto Nakano, Yuko Okuyama, and Hiroshi Hongo, “New Chiral Phosphinooxathiane Ligands for Palladium-Catalyzed Asymmetric Allylic Substitution Reactions” Tetrahedron Lett. 41, 4615-4618 (2000). →Link

環境創生工学系専攻

化学生物工学コース

有機合成化学

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